Ministerio de Ciencia e Innovación

Neuroinflammation and neurodegeneration

Multiple sclerosis and other demyelinating diseases constitute the paradigm of autoimmune diseases where neuroinflammation is the fundamental pathological feature. The relationships between neuroinflammation and neurodegeneration extend well beyond this group of diseases and permeate almost all neurodegenerative diseases. This phenomenon is present in almost all of them and constitutes a target of growing interest for the design of neuroprotective or neurorestorative therapeutic approaches, which are the focus of study in this cross-cutting program at CIBERNED.

Research Lines

  • Clinical, genetic, immunologic, and molecular characterization of patients with inflammatory central nervous system diseases.
  • Development of animal models of neuroinflammation and analysis of their relationships with neurodegeneration and brain proteinopathies.
  • Study of relationships between immunosenescence and the development of central or peripheral neurodegeneration.
  • Examination of environmental factors (climate, dietary habits, lifestyles, exposure to toxins, microbiota, etc.) potentially related to neuroinflammation and the development of neurodegeneration.
  • Development of new therapeutic strategies to combat neuroinflammation, neurodegeneration, and immunosenescence.


Research Groups

Jefe de Grupo

Institución Consorciada


Clemente López, Diego

Servicio de Salud de Castilla La Mancha

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Comabella López, Manuel

Fundación Hospital Universitario Vall d´Hebron - Institut de Recerca (VHIR)

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Matute Almau, Carlos

Universidad del País Vasco

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Otaegui Bichot, David

Asociación Instituto Biodonostia

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