Ministerio_de_Economia_y_Competitividad
Ministerio_de_Economia_y_Competitividad

Perfil del Grupo

Grupo José Rodriguez Alvarez

Instituto de Neurociencias UAB

Edificio M, Campus de Bellaterra
Universidad Autónoma de Barcelona

08193 Cerdanyola del Valles (Spain)

Tel.  +34 935 813 861
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Investigador Principal

José Rodriguez Alvarez

Research outline  

The benefits of modern medicine has caused an impressive increase in the average age of the population in developed countries. However, this scenario has allowed an increase in several diseases linked to ageing such as Alzheimer’s disease (AD). Research on AD was usually focused on the loss of neuronal populations but recently it has been described that an impairment in synaptic activity and the beginning of cognitive impairments seems to precede the neuronal death observed in Alzheimer disease. In this context we are interested in the study of the cellular and molecular mechanisms that are responsible for the early cognitive impairment observed in AD. In particular, we are focusing our efforts in the understanding the effect of ß-amyloid in synaptic GluA receptors (glutamate AMPA receptors) function and in the regulation of gene expression programs related to the cognitive deficits observed in early stages of Alzheimer’s disease. 

Publicaciones Destacadas

  • Parra-Damas, A., Valero, J., Chen, M., España, J., Martín, E., Ferrer, I., Rodríguez-Alvarez, J & C.A. Saura.CRTC1 activates a transcriptional program deregulated at early Alzheimer’s disease-related stages. J Neurosci. 34:5576-5787 (2014)
     
  • Fadó, R., Moubarak, R., Miñano-Molina, A.J., Barneda-Zahonero, B., Valero, J., Saura, C.A., Morán, J., Comella, J.X. & J. Rodríguez-Alvarez. X-linked inhibitor of apoptosis protein negatively regulates neurite outgrowth through interaction with cRAF and Trk. Sci Reports. 3:2397 (2013) doi: 10.1038/srep02397
     
  • Barneda-Zahonero, B., Servitja, J.M., Badiola, N., Miñano-Molina, A.J., Fadó, R., Saura, C.A. & J. Rodriguez-Alvarez. Nurr1 is required for NMDA receptor-mediated neuronal survival. J. Biol. Chem. 287:11351-11362 (2012)
     
  • Miñano-Molina, A.J., España, J., Martin, E. Barneda-Zahonero, B., Fadó, R., Solé, M., Trullás, R., Saura, C.A. & J. Rodríguez-Alvarez.  Soluble oligomers of amyloid-beta peptide disrupt membrane trafficking of AMPA receptors contributing to early synapse dysfunction. J Biol. Chem. 286:27311-27321 (2011)
     
  • España, J., Valero, J., Miñano-Molina, A., Masgrau, R., Martín,E., Guardia-Laguarta,C., Lleó, A., Giménez-Llort, L., Rodríguez-Alvarez, J. & C.A. Saura.ß-amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1J. Neurosci. 30:9402-9410 (2010)

 

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