Group Profile

Grupo Isabel Fariñas Gómez

Departamento de Biología Celular

Universidad de Valencia
Doctor Moliner 50
46100 Burjassot

Tel. +34
963 543 784 (office) 3246 (lab)
Fax +34 963 543 404

E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Principal Researcher

Isabel Fariñas Gómez

Research outline

Our laboratory studies two topics related to neurodegeneration and cell therapy:

  1. The study of cellular and molecular alterations that underlie degeneration of dopaminergic neurons. 
  2. The study of neural stem cell (NSC) self-renewal. 
Our current approach to the first topic is to analyze the function of molecules that have been implicated in familial cases of Parkinson´s disease, such as a-synuclein, by functional genomics in genetically modified mouse strains. In the second research line, our laboratory studies the molecular regulation of self-renewal in NSC populations, trying to understand the maintenance of multipotency and neurogenic potential as well as the preservation of long-term genetic stability. To do so, we are interested in identifying the signalling events that modulate self-renewal capacity in the NSC natural niches. We have chosen the mouse model due to the high flexibility of in vitro cellular systems and the existence of numerous genetics backgrounds available. 

Selected Publications

  1. Alcamo E.A.*, Chirivella L.*, Dautzenberg M., Dobreva G., Fariñas I., Grosschedl R., McConnell S. K.. SATB2 regulates callosal projection neuron identity in the developing cerebral cortex. Neuron 2008 Feb 7; 57(3):364-77. * equal contribution. Descargar PDF 

  2. Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone. Andreu-Agulló C, Morante-Redolat JM, Delgado AC, Fariñas I. Nat Neurosci. 2009 Dec;12(12):1514-23. Descargar PDF

  3. Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor. Wu HH, Bellmunt E, Scheib JL, Venegas V, Burkert C, Reichardt LF, Zhou Z, Fariñas I, Carter BD.Nat Neurosci. 2009 Dec;12(12):1534-41. Descargar PDF

  4. Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation. Folgueras AR, Valdés-Sánchez T, Llano E, Menéndez L, Baamonde A, Denlinger BL, Belmonte C, Juárez L, Lastra A, García-Suárez O, Astudillo A, Kirstein M, Pendás AM, Fariñas I, López-Otín C. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16451-6. Descargar PDF

  5. Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling. Ferron SR, Pozo N, Laguna A, Aranda S, Porlan E, Moreno M, Fillat C, de la Luna S, Sánchez P, Arbonés ML, Fariñas I. Cell Stem Cell. 2010 Sep 3;7(3):367-79.

  6. Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. Mira H, Andreu Z, Suh H, Lie DC, Jessberger S, Consiglio A, San Emeterio J, Hortigüela R, Marqués-Torrejón MA, Nakashima K, Colak D, Götz M, Fariñas I, Gage FH. Cell Stem Cell. 2010 Jul 2;7(1):78-89.

  7. Vulnerability of peripheral catecholaminergic neurons to MPTP is not regulated by alpha-synuclein. Cano-Jaimez M, Pérez-Sánchez F, Milán M, Buendía P, Ambrosio S, Fariñas I. Neurobiol Dis. 2010 Apr;38(1):92-103.

  8. Prosurvival effect of human wild-type alpha-synuclein on MPTP-induced toxicity to central but not peripheral catecholaminergic neurons isolated from transgenic mice. Pérez-Sánchez F, Milán M, Buendía P, Cano-Jaimez M, Ambrosio S, Rosenthal A, Fariñas I. Neuroscience. 2010 May 5;167(2):261-76.

  9. Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis. Ferrón SR, Marqués-Torrejón MA, Mira H, Flores I, Taylor K, Blasco MA, Fariñas I. J Neurosci. 2009 Nov 18;29(46):14394-407. Descargar PDF

  10. Dobreva, G.; Chahrour, M.; Dautzenberg, M.; Chirivella, L.; Kanzler, B.; Fariñas, I.; Karsenty, G.; Grosschedl, R. SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell, 125:971-986 (2006)
    Comment in “Minireviews”: Ellies, D.L.; Krumlauf, R. (2006) Bone formation: The nuclear matrix reloaded. Cell, 125:840-842.
    Descargar PDF

  11. Ferrón, S. R.; Andreu-Agulló, C.; Sánchez, P.; Mira, H.; Marqués-Torrejón M. A.; Fariñas, I. Ex vivo and in vivo assays to detect effects of exogenously added factors in the behavior of adult neural stem cells. Nature Protocols, 2:849-859 (2007). Descargar PDF

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